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archives

March 2011

CoESPRIT: A Library-Based Construct Screening Method for Identification and Expression of Soluble Protein Complexes.

By An Y, Meresse P, Mas PJ, Hart DJ.

- PLoS One. PMID: 21364980

Single isomorphous replacement phasing of selenomethionine-containing proteins using UV-induced radiation damage.

By Panjikar S, Mayerhofer H, Tucker PA, Mueller-Dieckmann J, de Sanctis D.

- Acta Crystallogr D PMID: 21206060

Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain.

By Langer K, Dian C, Rybin V, Müller CW, Petosa C.

- PLoS One. PMID: 21364925

Bilayer-Mediated Clustering and Functional Interaction of MscL Channels.

By Grage SL, Keleshian AM, Turdzeladze T, Battle AR, Tay WC, May RP, Holt SA, Contera SA, Haertlein M, Moulin M, Pal P, Rohde PR, Forsyth VT, Watts A, Huang KC, Ulrich AS, Martinac B.

- Biophys J. PMID:21354398

Highlight from the ESRF Structural Biology Beamlines

The structure of UvrA nucleotide excision repair protein in complex with modified DNA.
By Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M.

- Nat Struct Mol Biol. PMID:21240268
Data were collected at beamline ID23-2.


April 2011

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.

By Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso-Iltis C, Moulin M, Haertlein M, Callow P, Mély Y, Svergun DI, Moras D.

- Nat Struct Mol Biol. PMID:21478865

M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules.

By Gout E, Moriscot C, Doni A, Dumestre-Pérard C, Lacroix M, Pérard J, Schoehn G, Mantovani A, Arlaud GJ, Thielens NM.

- J Immunol. PMID:21490156

ORF-selector ESPRIT: A second generation library screen for soluble protein expression employing precise open reading frame selection.

By An Y, Yumerefendi H, Mas PJ, Chesneau A, Hart DJ.

- J Struct Biol. PMID: 21515383

Single isomorphous replacement phasing of selenomethionine-containing proteins using UV-induced radiation damage.

By Panjikar S, Mayerhofer H, Tucker PA, Mueller-Dieckmann J, de Sanctis D.

- Acta Crystallogr D PMID: 21206060

Highlight from the ESRF Structural Biology Beamlines

The structure of KSR2 in complex with MEK1. The phosphorylation activity of KSR2 using ATP (spheres) is essential in the construction of higher signalling complexes. See Brennan et al. Nature, 472, 366-369 (2011)
Data were collected at beamline ID14-4.


May 2011

Intrinsic disorder in measles virus nucleocapsids.

By Jensen MR, Communie G, Ribeiro EA Jr, Martinez N, Desfosses A, Salmon L, Mollica L, Gabel F, Jamin M, Longhi S, Ruigrok RW, Blackledge M.

- Proc Natl Acad Sci U S A. PMID:21613569

Single isomorphous replacement phasing of selenomethionine-containing proteins using UV-induced radiation damage.

By Panjikar S, Mayerhofer H, Tucker PA, Mueller-Dieckmann J, de Sanctis D.

- Acta Crystallogr D PMID: 21206060

Identification of the Elusive Hydronium Ion Exchanging Roles with a Proton in an Enzyme at Lower pH Values.

By Kovalevsky AY, Hanson BL, Mason SA, Yoshida T, Fisher SZ, Mustyakimov M, Forsyth VT, Blakeley MP, Keen DA, Langan P.

- Angew Chem Int Ed Engl.PMID:21604345

Highlight from the ESRF Structural Biology Beamlines

The structure of KSR2 in complex with MEK1. The phosphorylation activity of KSR2 using ATP (spheres) is essential in the construction of higher signalling complexes. See Brennan et al. Nature, 472, 366-369 (2011)
Data were collected at beamline ID14-4.


June 2011

Highlight from the ESRF Structural Biology Beamlines

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate By Phan et al., Nature, 474, 49–53 (2011)

- The data were collected at ESRF beamline ID23-1

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

By Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S.

- Proc Natl Acad Sci PMID:21670278

Variation in the organisation and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly.

By Vijayakrishnan S, Callow P, Nutley MA, McGow DP, Gilbert D, Kropholler P, Cooper A, Byron O, Lindsay JG.

- Biochem J. PMID: 21627584

Low resolution structure of a bacterial SLC26 transporter reveals a dimeric stoichiometry and mobile intracellular domains.

By Compton EL, Karinou E, Naismith JH, Gabel F, Javelle A.

- J Biol Chem. PMID:21659513


July 2011

Structural and Functional Insights of DR2231 protein, the MazG-like nucleoside triphosphate pyrophosphohydrolase from Deinococcus radiodurans.

By Goncalves AM, de Sanctis D, McSweeney SM.

- J Biol Chem. PMID: 21733847

Crenarchaeal CdvA Forms Double-Helical Filaments Containing DNA and Interacts with ESCRT-III-Like CdvB.

By Moriscot C, Gribaldo S, Jault JM, Krupovic M, Arnaud J, Jamin M, Schoehn G, Forterre P, Weissenhorn W, Renesto P.

- PLoS One. PMID: 21760923

13C-Labeled Heparan Sulfate Analogue as a Tool To Study Protein/Heparan Sulfate Interactions by NMR Spectroscopy etc...

By By Laguri C, Sapay N, Simorre JP, Brutscher B, Imberty A, Gans P, Lortat-Jacob H.

- J Am Chem Soc. PMID:21634378

Architecture of the Mediator head module.

By Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y.

- Nature. PMID:21725323


August 2011

Structural Characterization and Membrane Localization of ExsB from the Type III Secretion System (T3SS) of Pseudomonas aeruginosa.

By Izoré T, Perdu C, Job V, Atree I, Faudry E, Dessen A.

- J Mol Biol. PMID: 21839744

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH.

By Solomons J, Sabin C, Poudevigne E, Usami Y, Hulsik DL, Macheboeuf P, Hartlieb B, Göttlinger H, Weissenhorn W.

- Structure. PMID: 21827950

A thermodynamic switch modulates abscisic acid receptor sensitivity.

By Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL, Márquez JA.

- EMBO J. PMID: 21847091

Highlight from the ESRF Structural Biology Beamlines

Structure and Activity of a Novel Archaeal beta-CASP Protein with
N-Terminal KH Domains.

- Silva et al., (2011) Structure 19, 622-632.


September 2011

X-ray structure reveals a new class and provides insight into evolution of alkaline phosphatases.


By Bihani SC, Das A, Nilgiriwala KS, Prashar V, Pirocchi M, Apte SK, Ferrer JL, Hosur MV.

- PLoS One. PMID: 21829507

Direct cryocooling of naked crystals: are cryoprotection agents always necessary?

By Pellegrini E, Piano D, Bowler MW.

- Acta Crystallogr D PMID: 21931222

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH.

By Solomons J, Sabin C, Poudevigne E, Usami Y, Hulsik DL, Macheboeuf P, Hartlieb B, Göttlinger H, Weissenhorn W.

- Structure. PMID: 21827950

Direct determination of the base-pair force constant of DNA from the acoustic phonon dispersion of the double helix.


By van Eijck L, Merzel F, Rols S, Ollivier J, Forsyth VT, Johnson MR.

- Phys Rev Lett. PMID: 21929208

A thermodynamic switch modulates abscisic acid receptor sensitivity.

By Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL, Márquez JA.

- EMBO J. PMID: 21847091

Highlight from the ESRF Structural Biology Beamlines


A Dual Binding Mode for RhoGTPases in Plexin Signalling,

- By Bell HC., Radu Aricescu A., Jones EY, Siebold C. PLoS Biol 9(8): e1001134 (2011).

- Data were collected at the ESRF (ID23-2) and Diamond (I03).


October 2011

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA.


By Kowalinski E., Lunardi T., McCarthy AA., Louber J., Brunel J., Grigorov B., Gerlier D., and Cusack S.

- Cell. PMID: 22000019

Kinetic asymmetry of subunit exchange of homooligomeric protein as revealed by deuteration-assisted small-angle neutron scattering.


By Sugiyama M, Kurimoto E, Yagi H, Mori K, Fukunaga T, Hirai M, Zaccai G, Kato K.

- Biophys J. PMID: 22004758

Low-temperature chromophore isomerization reveals the photoswitching mechanism of the fluorescent protein padron.

By Regis Faro A, Carpentier P, Jonasson G, Pompidor G, Arcizet D, Demachy I, Bourgeois D.

- J Am Chem Soc. PMID: 21923132

Direct cryocooling of naked crystals: are cryoprotection agents always necessary?

By Pellegrini E, Piano D, Bowler MW.

- Acta Crystallogr D PMID: 21931222

Highlight from the ESRF Structural Biology Beamlines


Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
By Lebon G., Warne T., Edwards PC, Bennett K., Langmead CJ., Leslie AGW. & Tate C.G.

- Nature PMID:21593763

- Data were collected at the ESRF (ID23-2).