Small angle scattering instruments available for biology at PSB partner institutes include D22 and BM29. They are operated by ILL and ESRF/EMBL staff, respectively. Access is via a peer-reviewed proposal submission system at ILL and ESRF, either separately or with the possibility to ask for a joint SAXS/SANS experiment. While BM29 is dedicated exclusively to biological experiments (BioSAXS), about 10-15% of the D22/D11 instrument beamtime is dedicated to biology.
D22, D11 are small-angle neutron scattering instruments at ILL. Their q-range and high flux are ideal for studying most of biological macromolecular complexes and the variation of contrast (hydrogen/deuterium mix) enables to selectively observe the components involved in such complexes. Some sample environments (22-positions low-volume sample changer) and side equipments (temperature control, UV-Visible spectrophotometer) are also specifically designed for biological applications.
BM29 is a recently upgraded fully automated high throughput beamline at the ESRF dedicated to macromolecules in solution. It is operating with a sample changer robot or alternatively on-line size exclusion chromatography device both modes with automated data analysis for quality control and feedback. The improved beam characteristics result in reduced parasitic scattering, shorter exposure times (by a factor 10)
Website
http://www.esrf.eu/UsersAndScience/Experiments/MX/About_our_beamlines/BM29
http://www.ill.eu/instruments-support/instruments-groups/instruments/d22/description/instrument-layout/
http://www.ill.eu/instruments-support/instruments-groups/instruments/d11/description/instrument-layout/
Location:
Location D22, D11 – Guide hall n°2, cold guide H512;
BM29 beamline is located in ESRF Experiment hall 1
Access mode:
ESRF "SANS" BAG that enables users to access the SANS/SAXS platform through a single entry point via the ILL proposal system.
