Targeting DNA repair pathway in cancers – through the lens of melanoma antigens
Our genetic material is highly susceptible to mutations, either spontaneously or triggered by external stimuli such as UV and chemical carcinogens. Human cells employ an
How does the body prevent multiple sperm from fertilizing an egg?
According to the World Health Organization (WHO) around 15% of couples worldwide face infertility, with some cases linked to mutations in genes responsible for the
How is the production of reactive oxygen species activated in NADPH oxidase membrane enzymes? Lessons from the structure of a bacterial homologue
Lessons from the structure of a bacterial homologue During bacterial infections, neutrophils play a crucial role in defending the body by engulfing and destroying microorganisms
Tryptophan synthase crystals grown on the International Space Station facilitate novel neutron crystal structure
Single-crystal neutron diffraction is a powerful technique in structural biology that can accurately visualize the hydrogen atom positions in biomacromolecules. Because hydrogen atoms make up
Perturbing the active site of splicing machines as a new strategy for splicing inhibition
Splicing is a cellular process involving nearly all of our genes, and consisting in the removal of RNA sequences (introns) from precursor transcripts, while other
News from the M4D platform
We are glad to announce 2 major pieces of equipment have been integrated at the M4D platform. Since February this year, the cell imaging platform
Does the Sars-CoV-2 spike protein modulate High-Density Lipoprotein function?
Since the beginning of the COVID-19 outbreak in late December 2019, there has been a lot of talk about how the seriousness of the disease
Understanding how the cytokine storm propagates
When cells are put under stress from their environment they need to react. To fight stress, such as infection, several coping mechanisms, including the inflammatory
Integrative biology furthers the understanding of bioenergetics in Alzheimer’s disease Room
Alzheimer’s disease (AD) is an incurable neurodegenerative disease and cases are predicted to rise significantly in the next 30 years. The race is on to
Avian influenza adapts to humans by acquiring multivalency
Avian influenza viruses represent a recurring threat to human health. In particular highly pathogenic zoonotic avian strains, such as the currently circulating H5N1 subtype, can
Room Temperature Protein Electron Crystallography
Due to its charge, electron interacts strongly with matter. Electron crystallography can thus be carried out on nanometer-sized crystals that contain fewer unit cells than
CM02 is born
After several years of waiting, the France Cryo-EM project is becoming reality. This project will enable France to catch up its lack in term of
