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PSB Seminar – 25 April

Event date : Thu 25 April 2024

Prof. David Drew, Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, Sweden. https://www.su.se/english/research/research-groups/david-drew-s-research-group

Talk abstract

Transporting small molecules across cell membranes is an essential process in cell physiology. The uptake of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most cells. Here, I will present our multidisciplinary approach that has revealed important insights into the mechanism of glucose (GLUT) uptake and Na+/H+ exchange, which are important transport systems for our cells to utilize glucose as an energy source and for the regulation cytoplasmic and organellar pH. I will also present our recent structural insights into a sperm-specific Na+/H+ exchanger regulated by voltage – transforming the transporter into a signaling cascade that is essential in animals (metazoa) for sperm motility and fertilization.

Nature (2023). 623:193–201; Nature. (2020) 578 (7794):321-325; Nature (2015) 526(7573):397-401; Nature (2013) 501(7468):573-7.